PORTLAND, Maine (AP) — Public health authorities in Maine say thousands of doses of coronavirus vaccine exceeded temperature requirements during their shipment to the state.

Maine Center for Disease Control and Prevention director Dr. Nirav Shah said Tuesday the 4,400 doses of Moderna’s vaccine exceeded the required temperature during their journey to 35 sites in the state. He said the sites have set the vaccine doses aside and will receive replacement doses on Tuesday and Wednesday.

Shah says Operation Warp Speed and the U.S. Centers for Disease Control and Prevention are investigating how and why the error happened.

Maine has had more than 500 deaths from the virus since the start of the pandemic.

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